Vitamin D deficiency is associated with chronic pain disorder, depression, and several neurological disorders. 1, 2, 3, 4, 5, 6 The brain has an abundance of vitamin D receptors and there is evidence of a nonskeletal role of vitamin D in inflammation, immunity, and the metabolism of neurotransmitters. 6, 7, 8 In addition, vitamin D has been asso
The role of vitamin D deficiency on migraine chronicity has not been clearly identified. The pathogenic mechanism of migraine chronicity presumes to be associated with a neurotransmitter imbalance and upregulation of inflammatory pathways in CNS resulting in central amplification of peripheral pain signals. [ 9]
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Vitamin D is known to reduce oxidative stress and may therefore help prevent migraines and reduce sensitivity to migraine triggers. Studies have found that people with higher blood vitamin D levels are significantly less likely to experience migraine headaches than those with deficient vitamin D levels.

It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs.

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  • vitamin d deficiency and migraines